Mole Creek is a farming and forestry town in northern Tasmania, about half way between Launceston and Devonport.

It was originally called Western Marshes but later named Mole River in 1827 by Joseph Fossey (1788 – 1851) who was a surveyor who arrived in Van Diemen's Land in 1826 as an employee of the Van Diemen's Land Company.

It is believed that he named it as such either because of the way the creek seems to “burrow underground at different places” or because of underground steam that was “seen arising” from some underground source. The first settlement was in the 1880s, the first settler being a John Howe.

The area has a large number of underground limestone caves, the most famous being the Marakoopa Cave and the King Solomon’s Cave.

The Marakoopa Cave is the larger of the two, and has a spectacular glow worm display. It is the only glow worm cave in Tasmania open to the public. The name "Marakoopa" is from the Tasmanian Aboriginal word for "handsome".
King Solomon Cave is slightly smaller, although still spectacular and more conveniently located.
The cave was named for one of the formations, which visitors see approximately in the middle of the regularly conducted forty minute tours.

Mole Creek and the surrounding areas produce Australia’s famous leatherwood honey – derived from the blossom of the Leatherwood tree which grows only in Tasmania’s rain forests. The area is also a prime habitat for the Tasmanian devil and the Trowunna Wildlife Park is a popular attraction in the area and renowned for its devil conservation and breeding programme.

Howe’s General Store was built around 1890 and became the centre of commerce in the small township and the same family constructed a small boarding house on the site to cater for the emerging ‘tourist market’. The boarding house has since been demolished but was a great favourite holiday destination for former Australian Prime Minister Joseph Lyons.

The former store was closed and sold in 1986 shortly after the railway was shut down and it was then converted to a guest house for accommodation – a purpose it still serves today. The railway was opened to Mole Creek on 5 April, 1890. Throughout its existence, it carried mostly timber destined for the paper mill at Burnie and, in later days, wood chips for Bell Bay.

Passenger services were mostly railcars after the 1920s. The line closed in 1992, it having been out of service since 1985.
At the 2006 census, Mole Creek’s population was listed as 223.